Figure 2From: Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatinIsolated fibers from YS mice exhibit increased sensitivity to simvastatin compared to WT mice. Dose–response curves from isolated WT and YS FDB fibers incubated for 3 minutes in respective doses of simvastatin. Data points reflect peak cytosolic Ca2+ change from baseline, indicating that fibers from YS mice respond to simvastatin at lower doses than WT fibers. Fibers were used only at a single simvastatin concentration. Each data point represents the mean cytosolic Ca2+ response from a minimum of three fibers taken from three separate mice. Ca2+, calcium; FDB, flexor digitorum brevis; WT, wild type; YS, Y524S.Back to article page