Fig. 4

Breeding scheme for the generation of dystrophin/GRAF1-deficient mice. Genotypes of experimental mice are denoted in gray boxes. Graf1^Wt/Wt; X^WtX^Wt or X^WtY = wild-type; Graf1^Gt/Gt; X^WtX^Wt or X^WtY = Graf1-deficient; Graf1^Wt/Wt; X^mdxX^mdxor X^mdx/Y = dystrophin-deficient; Graf1^Gt/Wt;X^mdxX^mdx or X^mdx/Y = Graf1 haploinsufficient/dystrophin-deficient; Graf1^Gt/Gt; X^mdxX^mdxor X^mdx/Y = Graf1/dystrophin double-deficient