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Table 2 Top 50 genes significantly associated with age across 361 samples

From: A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging

Gene

Min (p)

Max |β|

H3F3B

3.39E-13

0.0098

AHNAK

6.87E-12

0.0086

HOXB2

1.01E-11

−0.0184

CRIM1

5.34E-11

0.0124

NAP1L1P3

9.74E-11

0.0154

ARFGAP2

3.56E-10

0.0069

WDR6

4.47E-10

0.0069

DLEU1

8.61E-10

−0.0117

USP6

1.43E-09

0.0133

TCF25

2.70E-09

0.0064

SCN4B

3.13E-09

−0.0289

ZNF274

3.87E-09

0.0129

HDAC4

4.04E-09

0.0155

SH3BP5

5.04E-09

0.0114

SART3

5.32E-09

0.0050

CASC3

9.73E-09

0.0061

CIRBP

1.14E-08

0.0091

HIST1H2BN

1.49E-08

−0.0065

FUBP1

1.74E-08

0.0058

FAM171A1

1.94E-08

−0.0113

NPPA

1.97E-08

−0.0048

TMEM59L

2.39E-08

−0.0080

UBE2O

2.79E-08

−0.0060

FEZ2

2.83E-08

0.0126

ALS2CL

3.15E-08

−0.0063

C1S

3.22E-08

0.0137

RXRG

3.23E-08

−0.0095

NT5C2

3.64E-08

0.0115

TRMT112

4.42E-08

0.0116

PRNP

4.68E-08

0.0094

NOL9

6.31E-08

0.0049

RBM10

6.66E-08

0.0056

ANP32B

6.71E-08

0.0092

TOMM40L

6.74E-08

−0.0144

HTR5A

7.21E-08

−0.0051

SEC24C

7.78E-08

0.0060

BUB3

7.98E-08

0.0036

DAAM2

8.92E-08

−0.0091

HSPA1A

8.93E-08

0.0091

SEZ6L2

9.12E-08

−0.0046

MRPL4

9.38E-08

−0.0080

CMC2

1.04E-07

−0.0091

NR1D1

1.04E-07

−0.0054

ENDOG

1.11E-07

−0.0126

MRPL48

1.25E-07

−0.0066

FRAT2

1.31E-07

−0.0064

SYNRG

1.31E-07

0.0040

PPIC

1.38E-07

−0.0076

POMT1

1.47E-07

0.0061

DECR2

1.65E-07

0.0043

  1. The minimum p and maximum β values were calculated for genes present in both array datasets, adjusted for sex and study effect. A positive β value implicates increasing gene expression with age. For the full list of 957 genes, see Table S2 in Additional file 2