Fig. 2From: Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor musclePresence of mtDNA deletions in COPD locomotor muscle corresponds to higher levels of DNA damage, smoking history, and aerobic capacity. a Higher levels of oxidatively damaged guanosine (pg of 8-OHdG per mL of total DNA) in COPD patients with mtDNA deletions (456.8 ± 45.7) compared to patients without detectable mtDNA deletions (196.9 ± 28.6; ***P < 0.001). b Higher number of smoking pack-years in COPD patients harboring mtDNA deletions (66.3 ± 7.5) compared to COPD patients without detectable mtDNA deletions (38.0 ± 7.3). c Lower maximal oxygen consumption in COPD patients harboring mtDNA deletions (33.7 ± 2.4 % predicted) compared to COPD patients without detectable mtDNA deletions (45.6 ± 5.6 %). Graphs show mean ± SEM (*P < 0.05)Back to article page