Fig. 1From: Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosisDysregulation of complement components in tibialis anterior muscle (TA) of hSOD1G93A mice at three different stages of disease progression. Panels a to f show the mRNA expression profiles of the following complement components: C1qB (a, classical pathway), C4 (b, classical/lectin pathway), fB (c, alternative pathway), C3 (d, central component), CD55 (e, regulator), and CD59a (f, regulator) in TA muscle of hSOD1G93A mice (SOD1, black bars) relative to wild-type (WT, white bars) mice during onset (OS; postnatal day 70 (P70)), mid-symptomatic (MS; postnatal day 130 (P130)) and end-stage of disease (ES; postnatal day 175 (P175)). Data are expressed as means ± SEM (n = 5 mice/group, * p < 0.05, ** p < 0.01, Student t test 6)Back to article page