Fig. 4

C5aR1 is localised to infiltrating CD11b⁺ macrophages in the tibialis anterior (TA) muscle of wild-type (WT) and hSOD1^G93A (SOD1) transgenic mice. Panels a to h show double immuno-labelling of C5aR1 (red) with cellular marker (green) for macrophages (CD11b; a to c for WT (detailed in d); e to h for SOD1 mice) in the TA muscle of WT and SOD1 mice at end stage disease. C5aR1 was co-localised with CD11b positive macrophages in WT and SOD1 mice (yellow arrows in d and h). Scale bar = 20 μm