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Fig. 3 | Skeletal Muscle

Fig. 3

From: Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle

Fig. 3

Reduced Sox11 expression and 3D-genome alterations at Sox11 locus in muscle stem cells with age. A UMAP of all cells from young and old mice, MuSCs highlighted in color. B Clustering and gene expression analysis on MuSCs only, highlighted in panel (A); gene expression plots (left panel) and violin plots (based on age) identifies various differentiation-related transcripts are reduced with age identifies significantly reduced Sox11 expression in MuSCs from old mice. C Comparison of Hi-C contact maps (10-kb resolution) surrounding Sox11 locus between young (top) and aged (bottom) FISCs. The yellow triangle indicates the interaction region harboring Sox11 locus. Bottom, genome browser tracks showing the RNA-seq in young and aged FISCs. D Bar graph showing the mean FPKM values of Sox11 in young and aged FISCs. n = 3 for each group

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Skeletal Muscle

ISSN: 2044-5040

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