DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults

Burton, Mark A.; Garratt, Emma S.; Hewitt, Matthew O.; Sharkh, Hanan Y.; Antoun, Elie; Westbury, Leo D.; Dennison, Elaine M.; Harvey, Nicholas C.; Cooper, Cyrus; MacIsaac, Julia L.; Kobor, Michael S.; Patel, Harnish P.; Godfrey, Keith M.; Lillycrop, Karen A.

doi:10.1186/s13395-023-00326-y

Skeletal Muscle

Table 3 HOMA2-IR-enriched pathways in myoblasts from aged skeletal muscle; top 10 Gene Ontology (GO) biological process and top 10 KEGG pathways shown

From: DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults

Genes	Category	Description	FDR	Genes
GO biological process
7	Bio process	Tissue homeostasis	6.60E-04	IHH\|CTNNB1\|OCLN\|CDH23\|TNFSF11\|KIAA1211\|ACACA
8	Bio process	Anatomical structure homeostasis	7.50E-04	IHH\|CTNNB1\|OCLN\|PARK2\| CDH23\|TNFSF11\|KIAA1211\| ACACA
6	Bio process	Regulation of JNK cascade	0.0019	MAPK8IP3\|APP\|HIPK3\|PARK2\| TNFSF11\|AKT1
9	Bio process	Regulation of MAPK cascade	0.0038	MAPK8IP3\|APP\|PIK3CB\|MST1R\|HIPK3\|CTNNB1\|PARK2\| TNFSF11\|AKT1
12	Bio process	Generation of neurons	0.0038	SEMA4G\|MAPK8IP3\|CELSR1\|APP\|PIK3CB\|IHH\|GAK\|PLAG1\|CTNNB1\|PARK2\|CDH23\|AKT1
10	Bio process	Regulation of transferase activity	0.0038	MAPK8IP3\|APP\|PIK3CB\|MST1R\|HIPK3\|IRS1\|CTNNB1\|PARK2\|TNFSF11\|AKT1\|
6	Bio process	Regulation of protein kinase b signalling	0.0038	APP\|PIK3CB\|MST1R\|IRS1\| TNFSF11\|AKT1
4	Bio Process	Regulation of oxidative stress-induced cell death	0.005	APP\|CTNNB1\|PARK2\|AKT1
5	Bio process	Positive regulation of protein kinase b signalling	0.0075	APP\|PIK3CB\|MST1R\|IRS1\| TNFSF11
12	Bio process	Positive regulation of cell communication	0.008	MAPK8IP3\|APP\|PIK3CB\|IHH\|MST1R\|IRS1\|C2CD2L\|CTNNB1\|PARK2\|CYP19A1\|TNFSF11\| AKT1
KEGG
4	KEGG	AMPK signalling pathway	0.0141	PIK3CB\|IRS1\|AKT1\|ACACA
3	KEGG	Longevity regulating pathway	0.0141	PIK3CB\|IRS1\|AKT1
3	KEGG	Longevity regulating pathway—multiple species	0.0141	PIK3CB\|IRS1\|AKT1
4	KEGG	Insulin signalling pathway	0.0141	PIK3CB\|IRS1\|AKT1\|ACACA
3	KEGG	Prolactin signalling pathway	0.0141	PIK3CB\|TNFSF11\|AKT1
3	KEGG	Regulation of lipolysis in adipocytes	0.0141	PIK3CB\|IRS1\|AKT1
5	KEGG	Alzheimer disease	0.0141	APP\|PIK3CB\|IRS1\|CTNNB1\| AKT1
3	KEGG	Chagas disease	0.0141	PIK3CB\|GNAL\|AKT1
4	KEGG	Hepatitis C	0.0141	PIK3CB\|CTNNB1\|OCLN\|AKT1
4	KEGG	Proteoglycans in cancer	0.0141	PIK3CB\|IHH\|CTNNB1\|AKT1

GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes

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ISSN: 2044-5040

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