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Fig. 3 | Skeletal Muscle

Fig. 3

From: Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy

Fig. 3

NAM supplementation improves NAD+ levels in striated muscles of golden retriever muscular dystrophy. A Quantification of skeletal muscles NAD.+ content from WT (n = 4), GRMD (n = 3), and NAM-treated GRMD (n = 3) dogs. Bars indicate means ± standard errors of means, and numbers above columns indicate P-values. Differences were analyzed by one-way ANOVA. B Immunoblots showing total PARylated protein level expression with PAR antibody in skeletal muscle from GRMD (n = 2) dogs treated or not with NAM. Ponceau was shown as loading control. The bar graphs represent PARylated protein relative expression (mean ± standard error of means). C Representative immunoblots showing Nampt and NRK2 protein level expression in skeletal muscle from GRMD dogs treated or not with NAM. Ponceau was shown as loading control. The bar graphs represent PARP-1 and Nampt protein relative expression (mean ± standard error of means) (n = 3 dogs for each condition)

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Skeletal Muscle

ISSN: 2044-5040

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