Fig. 4
From: The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Distinct pathways are dysregulated in ∆Ig3-MuSK TA and soleus. A and B Gene ontology pathway analysis of top 100 upregulated and downregulated biological process pathways in ∆Ig3-MuSK TA (A) and soleus (B) (see Table S3). Note the number of highly significant pathways in soleus (adjusted p-values between 10−7 and 10−12) compared to TA. Selective enrichment in soleus down pathways was related to translation including those involving ribosome biogenesis as well as mRNA and ncRNA metabolism. Soleus up pathways included those involved in ECM and inflammation. C Venn diagram showing the number of shared and unique downregulated and upregulated pathways between ∆Ig3-MuSK TA and soleus (see Table S3). Note that ≤ 5% of pathways are shared in any of the comparisons. No shared pathways were observed when comparing TA down and soleus up