Fig. 3
From: N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
CK8-μDys5 reduces urinary titin in the presence of 40–50% microdystrophin-positive fibers. A Group 1 (microdystrophin < 10% positive fibers in the vastus lateralis) shows no changes in urinary titin or serum CK activity 360 days post-treatment. B Group 2 (microdystrophin > 10% positive fibers in the vastus lateralis) shows decreases in urinary titin at day 180 and 360, while serum CK activity was trending at day 180, but significantly changed at day 360 only