Fig. 4

Circulating titin shows changes at lower levels of expressed microdystrophin when compared to CK-MM in preclinical DMD models. A The Somalogic aptamer detects the N terminal portion (AA 1–194) of the titin protein. This region was predicted to be highly conserved across mice, dogs, and humans. B Titin showed a response in vastus lateralis at > 50% microdystrophin levels, while an increase or no change was observed in CK-MM in the GRMD dogs 90 days post-treatment. C Circulating titin was also decreased in the plasma of mdx mice at lower levels of expressed microdystrophin in quadriceps when compared to CK-MM