Table 1 Altered protein expression in human urine
From: N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
|  | SeqId | SomaId | TargetFullName | UniProt | Healthy relative fluorescent units (average +/- SD) | DMD relative fluorescent units (average +/- SD) | Fold change (DMD/healthy) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Upregulated with disease | 11,352–42 | SL006679 | Titin | Q8WZ42 | 623.7 | +/-  | 604.4 | 46,605.9 | +/- | 30,350.3 | 74.7 |
24,967–4 | SL008346 | Protocadherin-1 | Q08174 | 69.4 | +/- | 24.5 | 1016.6 | +/- | 1049.2 | 14.7 | |
15,324–58 | SL005628 | Ferritin light chain | P02792 | 4359.3 | +/-  | 2279.8 | 53,953.3 | +/- | 55,065.0 | 12.4 | |
5934–1 | SL000420 | Ferritin | P02794|P02792 | 4943.7 | +/-  | 2603.2 | 54,607.3 | +/- | 53,308.2 | 11.0 | |
12,649–80 | SL004917 | Malate dehydrogenase, mitochondrial | P40926 | 318.0 | +/-  | 615.5 | 3368.6 | +/- | 7239.0 | 10.6 | |
13,534–20 | SL008132 | Myomesin-2 | P54296 | 76.1 | +/-  | 15.2 | 738.3 | +/- | 963.5 | 9.7 | |
15,534–26 | SL004917 | Malate dehydrogenase, mitochondrial | P40926 | 171.4 | +/-  | 239.2 | 1260.7 | +/-  | 2549.2 | 7.4 | |
3042–7 | SL000164 | Myoglobin | P02144 | 250.9 | +/-  | 127.6 | 1752.3 | +/- | 1724.5 | 7.0 | |
17,435–43 | SL008038 | Electron transfer flavoprotein subunit alpha, mitochondrial | P13804 | 274.0 | +/-  | 92.1 | 1850.0 | +/- | 4174.9 | 6.8 | |
2942–50 | SL000396 | Cytochrome c | P99999 | 1101.8 | +/-  | 759.7 | 6108.9 | +/-  | 5064.5 | 5.5 | |
Downregulated with disease | 13,671–40 | SL000401 | Neutrophil elastase | P08246 | 20,227.6 | +/-  | 35,004.5 | 1404.9 | +/- | 1240.7 | -14.4 |
6557–50 | SL008774 | Leucine-rich repeat-containing protein 15 | Q8TF66 | 30,992.7 | +/-  | 31,754.8 | 1970.7 | +/- | 3220.1 | -15.7 | |
2796–62 | SL000424 | Fibrinogen | P02671|P02675|P02679 | 15,869.5 | +/-  | 33,798.1 | 879.0 | +/- | 1009.3 | -18.1 | |
3074–6 | SL003309 | Lipopolysaccharide-binding protein | P18428 | 2607.0 | +/-  | 5621.3 | 130.4 | +/- | 108.4 | -20.0 | |
2381–52 | SL000319 | Complement C5 | P01031 | 2456.8 | +/- | 5737.2 | 113.2 | +/-  | 19.9 | -21.7 | |
10,620–21 | SL000548 | Beta-microseminoprotein | P08118 | 21,789.0 | +/- | 31,754.2 | 559.6 | +/- | 371.2 | -38.9 | |
4330–4 | SL000062 | Prostate-specific antigen | P07288 | 21,034.7 | +/- | 32,186.5 | 56.0 | +/- | 13.4 | -375.4 | |
8468–19 | SL000062 | Prostate-specific antigen | P07288 | 33,404.9 | +/- | 50,720.0 | 79.1 | +/- | 10.4 | -422.2 | |
21,232–39 | SL002764 | Benign prostate-specific antigen | P07288 | 38,882.1 | +/- | 58,563.6 | 82.4 | +/- | 10.0 | -472.0 | |
13,699–6 | SL000062 | Prostate-specific antigen | P07288 | 16,810.9 | +/-  | 26,057.2 | 33.9 | +/-  | 5.8 | -495.9 | |