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Figure 1 | Skeletal Muscle

Figure 1

From: Muscle membrane repair and inflammatory attack in dysferlinopathy

Figure 1

A schematic model for muscle membrane repair. (A) In uninjured muscle, the intact sarcolemma separates the intracellular environment from the hostile extracellular environment. (B) Membrane disruption leads to Ca2+ influx, oxidant entry and cholesterol unfurling. Membrane repair vesicles are transported towards the damage site by the motor proteins kinesin and myosin, and this process may be facilitated by Mitsugumin 53 (MG53) in the oxidation/cholesterol-dependent manner. The vesicles dock via oxidized MG53 and fuse with each other and with the plasma membrane possibly mediated by annexin, SNAREs and dysferlin in the presence of Ca2+. (C) A membrane "patch" is consequently formed, which resealed the membrane lesion.

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