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Figure 1 | Skeletal Muscle

Figure 1

From: Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients

Figure 1

Cross species deregulation of ubiquitin-proteasome in OPMD. A) Venn-diagram displaying the overlap in OPMD-deregulated genes in UPS across species. In mice and Drosophila, OPMD-deregulated genes should be consistently deregulated in at least two time points. The total number of genes in UPS is indicated in italics. The list of OPMD-deregulated UPS genes is in Additional File 2. B) Transcriptional changes of selected genes in UPS in different organisms. Histograms display the log2(ratio) of the measured expression values in Drosophila (white bars), mice (gray bars), and humans (black bars). Significant changes with the adjusted P < 0.05 are indicated by *. C) RT Q-PCR validation of selected deregulated genes in UPS was carried out on quadriceps (i) and soleus (ii) muscles of six-week-old mice. Histograms show the measured expression values for A17.1 and FVB mice using Q-PCR. Significant changes of measured expression values of A17.1 mice as compared to FVB with the P < 0.05 are indicated by *.

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Skeletal Muscle

ISSN: 2044-5040

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