Figure 1
From: T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases
Triad organization in skeletal muscle. Left: Electron micrograph of a triad junction. A central T-tubule is flanked on both sides by a terminal cisternae element from the sarcoplasmic reticulum. Arrows indicate electron-dense junctional feet corresponding to the ryanodine receptor-dihydhropyridine receptor complex. Right: Schematic representation of a mammalian muscle sarcomere and surrounding membranes. T-tubules shown in gray are specialized invaginations of the sarcolemma. The elaborated sarcoplasmic reticulum network is shown in blue. Note the close proximity of T-tubules and terminal cisternae of the sarcoplasmic reticulum (adapted from [104]; ©2007 by Pearson Education, Inc.).