Figure 7
From: Regulation of DMD pathology by an ankyrin-encoded miRNA
miR-486 is an important regulator of PTEN/AKT signaling in normal and dystrophic muscle. Schematic of miR-486 regulation of PTEN/AKT pathway upstream and downstream signaling components in skeletal muscle is shown. Regulation of the PTEN/AKT pathway in turn regulates FOXO1, which is a well-characterized regulator of p21 and p27 in skeletal muscle.