Figure 4From: Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervationA summary of the signal transduction pathways activated in SOD1G93A transgenic mice. The toxic effects of SOD1G93A induce a local accumulation of reactive oxygen species which affects the Akt pathways, promoting muscle atrophy. The later motor neuron degeneration leads to more severe muscle atrophy and to a shift in fiber-type composition (see text of the results section for details).Back to article page