Skip to main content
Figure 4 | Skeletal Muscle

Figure 4

From: Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation

Figure 4

A summary of the signal transduction pathways activated in SOD1G93A transgenic mice. The toxic effects of SOD1G93A induce a local accumulation of reactive oxygen species which affects the Akt pathways, promoting muscle atrophy. The later motor neuron degeneration leads to more severe muscle atrophy and to a shift in fiber-type composition (see text of the results section for details).

Back to article page