Age-dependent increases in body weight and glucose tolerance in Pparδ -cKO mice. (A) and (B) Body weights of female wild-type mice and mutant littermates at two and nine months old (N = 6). (C) and (D) Blood glucose concentration at different time points following intraperitoneal injection of glucose (2 g/kg). The mice were fasted for three hours prior to glucose injection. Glucose concentration was measured using an ACCU-CHEK Active blood glucose meter system (Roche Diagnostics, Indianapolis, IN, USA) (N = 3 pairs of female littermates). (E) and (F) Area under the curve (AUC) analysis the of glucose tolerance test results shown in parts (C) and (D), respectively.