Figure 6

Dystrophic features of laminin α2 chain muscle. Hematoxylin and eosin staining of triceps and diaphragm cross-sections from a 3.5-week-old dy^3K/dy^3Kmouse reveals fiber-size variability with predominance of small atrophic fibers. Regenerating fibers with centrally located nucleus and wide-spread fibrosis (green arrows) are also hallmarks of laminin α2 chain-deficient muscular dystrophy. Inset shows a higher magnification of dy^3K/dy^3Ktriceps.