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Figure 1 | Skeletal Muscle

Figure 1

From: IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

Figure 1

Mitochondrial content, biogenesis and morphology are altered during the progression of cachexia. ApcMin/+ mice were grouped by percentage of body weight loss to study muscle oxidative capacity during the progression of cachexia. A) Mitochondrial content as determined by the mitochondrial:nuclear DNA ratio. B) Representative Western blot of cytochrome C, CoxIV and PGC-1α protein expression throughout the progression of cachexia. C) Cytochrome C, D) CoxIV and E) PGC-1α protein expression normalized to weight stable mice. Representative EM images of intramuscular mitochondria in F) wild-type, G) ApcMin/+ mice with mild cachexia and H) ApcMin/+ mice with severe cachexia. I) Mitochondrial size and J) mitochondrial size distribution. Values are means ± SE. Significance was set at P <0.05. † Signifies different from weight stable groups. $ Signifies difference from mice with 6 to 19% body weight loss. WS, weight stable.

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