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Figure 5 | Skeletal Muscle

Figure 5

From: IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

Figure 5

IL-6 over-expression induced muscle wasting and reduced PGC-1α which are rescued with exercise training. ApcMin/+ mice underwent 12 weeks of moderate exercise training or served as sedentary cage controls and over-expressed circulating IL-6 or received a control vector. A) Gastrocnemius muscle mass. B) Representative Western blot of cytochrome C, CoxIV and PGC-1α protein in the gastrocnemius of ApcMin/+ mice. C) Cytochrome C, D) CoxIV and E) PGC-1α protein expression normalized to sedentary mice treated with the control vector. F) Upper - representative Western blot of 4-hydroxynonenal (4HNE)-modified proteins; lower - 4HNE-modified protein expression normalized to sedentary control mice. Values are means ± SE. Significance was set at P <0.05. CC, cage control; ME, main effect;. Wt, wild-type. * Signifies the difference from cage control vector mice.

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