Figure 7

Autophagy and ubiquitin dependent proteolysis are induced with IL-6 over-expression and attenuated with exercise training. A) Representative Western blot of Atg5, Beclin1 and LC3β protein in the gastrocnemius of Apc^Min/+ mice. B) Atg5, C) Beclin1 and D) LC3β protein expression normalized to sedentary cage control mice. E) Atrogin1 mRNA. F) C2 and G) C7 proteasomal subunit mRNA. Data are normalized to cage control groups for wild-type and Apc^Min/+ mice. Values are means ± SE. Significance was set at P <0.05. *Signifies the difference from cage control vector mice. † Signifies the difference within IL-6 treatment.