Figure 8
IL-6 treatment on C2C12 myotubes induces FIS1 expression and a reduction in PGC-1α mRNA. A) Representative Western blot of FIS1, Cytochrome C and CoxIV protein in C2C12 myotubes treated with 0, 20 and 100 ng/ml of IL-6. B) FIS1, C) Cytochrome C and D) CoxIV C protein expression and PGC-1α mRNA E) expression normalized to C2C12 myoblasts treated with vehicle control (0 ng/ml IL-6). Values are means ± SE. Significance was set at P <0.05. *Signifies the difference from 0 ng/ml control.