Figure 1
From: Metabolic remodeling agents show beneficial effects in the dystrophin- deficient mdx mouse model
Effect of dystrophin deficiency on mitochondrial mass and activity. (A) Isolated EDL fibers were stained with NAO dye to assess mitochondrial mass (n = 3 animals and 30 fibers per muscles). Pictures of the dye fluorescence were taken at the same setting. Fluorescence was quantified with ImageJ. (B) LDH enzyme activity was measured in TA muscle extracts (n = 6). (C) Isometric tetanic maximal force on EDL muscle from mdx and WT mice (n = 6). (D) Fatigue force measurements of EDL muscles from WT and mdx mice (n = 6). Data are means ± SE. * P < 0.05 vs. WT mice. *** P < 0.001 vs. WT mice.