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Figure 2 | Skeletal Muscle

Figure 2

From: Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

Figure 2

L-158809 reduces fibrosis and inflammation in the muscles of dyW/dyWmice. (A) Masson trichrome staining showed higher collagen content (blue) in triceps and diaphragm muscles of dyW/dyWwhen compared with dyW-L158 mice. (B) Average amount of fibrotic area relative to wild-type (WT) muscles. L-158809 treatment more than halved the fibrotic area in triceps and diaphragm muscles (n ≥ 4). (C) Measurement of the amount of hydroxyproline as an indicator of fibrosis. L-158809 treatment of dyW/dyWmice reduced the hydroxyproline amount in triceps muscle (n = 3). (D) F4/80 staining of macrophages in diaphragm muscles. (E) L-158809 treatment reduced the number of macrophages in muscles of dyW/dyWmice (n ≥ 4). All values represent the mean ± SEM. One-way ANOVA: **P ≤ 0.001; * P ≤ 0.05; n.s. (non-significant) P > 0.05. Scale bar = 50 μm.

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