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Figure 3 | Skeletal Muscle

Figure 3

From: Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

Figure 3

L-158809 reduced muscle-fiber loss but did not change fiber-size distribution in dyW/dyWmuscles. (A) L-158809 (dyW-L158) stabilized the loss of muscle fibers in dyW/dyWtriceps muscle, but only tended to reduce fiber loss in the diaphragm (n = 6). (B,C) L-158809 did not normalize the shift of fiber sizes to smaller fibers, either (B) in triceps or (C) in diaphragm muscle of dyW/dyWmice (n ≥ 4). (D) The minimal Feret`s diameter coefficient was unchanged by L-158809 (n ≥ 4). (E) L-158809 increased the cross-sectional area in both mid-belly triceps (P = 0.0007) and diaphragm (P = 0.0024) muscles (n ≥ 4). All values represent the mean ± SEM. P-values (one-way ANOVA): **P ≤ 0.001; * P ≤ 0.05; n.s. (non-significant) P > 0.05.

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