Figure 3
From: A role for RNA post-transcriptional regulation in satellite cell activation
Binding genes are enriched during satellite cell activation. Gene expression changes unique to wild type satellite cells occurring within 12 h post-muscle injury were further analyzed by gene ontology. The general Molecular Function GO categories of Binding (P = 7.03 × 10-43), Structural molecule activity (P = 4.97 × 10-4), Catalytic activity (P = 1.46 × 10-3), Transcription regulator activity (P = 0.0229), and Enzyme regulator activity (P = 0.0521) were identified by DAVID as enriched when comparing satellite cells isolated 12 h post-muscle injury to freshly isolated satellite cells (A). Specific Molecular Function GO terms including RNA binding, unfolded protein binding, and actin binding were enriched an average of 1.5-fold when comparing satellite cells from injured and uninjured muscle as identified by three independent algorithms including ProfCom, FunNet, and DAVID (B). The dotted line marks a 1.5-fold enrichment threshold. Asterisks mark GO terms with an average enrichment ≥ 1.5-fold.