Skip to main content
Figure 4 | Skeletal Muscle

Figure 4

From: A role for RNA post-transcriptional regulation in satellite cell activation

Figure 4

RNA post-transcriptional modification is the most enriched biological network. Gene expression changes unique to wild type satellite cell activation were subjected to IPA 9.0 (Ingenuity® Systems, http://www.ingenuity.com) network analysis and RNA Post-Transcriptional Modification, Developmental Disorder, Genetic Disorder (P ≤ 10-34) emerged as the associated biological functions in the top ranked interaction network with the canonical pathways Processing of RNA (17 blue dotted lines, P ≤ 4.44e-22) and Splicing of RNA (15 orange dotted lines, P ≤ 7.64e-20) comprising 50% of this network. The functions of these genes in muscle disease and cell fate decisions are listed in Table 4. Red indicates genes down-regulated and green indicates genes upregulated with the intensity denoting the increase or decrease in fold change. The data compares genes unique to wild type satellite cells isolated 12 h post-injury to satellite cells isolated from uninjured skeletal muscle.

Back to article page