A role for RNA post-transcriptional regulation in satellite cell activation

Skeletal Muscle

Table 4 Genes in the top ranked network associate with muscle function, muscle disease, or fate determination

Genes	Relevant role/Disease/Expression	Reference
Luc7l	Regulation of muscle differentiation	[45]
Snrpn	Prader-Willi syndrome	[46]
Polr2a	Positive regulation of embryonic stem cells	[47]
Htatsf1	Expression in developing limb bud	[48]
Zbtb3	Expression in developing limb bud	[48]
Supt5h	Expression in developing limb bud	[48]
Tcerg1	Expression in developing limb bud	[48]
Pqbp1	Facilitates neuronal proliferation and maturation; Expression in developing limb bud	[48, 49]
Snrpb	Spinal muscular atrophy; Expression in developing limb bud and somite	[7, 48]
Snrpa1	Spinal muscular atrophy	[50]
Syncrip	Spinal muscular atrophy	[50]
Sf1	Expression in developing limb bud	[48]
AP3D1	Regulation of progenitor cell competence	[51]
Hnrnpr	Expression in developing limb bud	[48]

Fourteen of the thirty-five genes in the top ranked biological network as identified by IPA v9.0 (Ingenuity® Systems, http://www.ingenuity.com) have defined functions in muscle or cell fate determination as determined with the associated references.

ISSN: 2044-5040