From: Alveolar rhabdomyosarcoma – The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis
Gene | Description | Regulation | References | PF target |
---|---|---|---|---|
ABAT | 4-Aminobutyrate aminotransferase; | Up | Yes | |
ACTC | Actin, alpha, cardiac muscle 1 | Up | Yes | |
ADAM10 | A disintegrin and metalloproteinase domain 10 | Up | Yes | |
ADRA2A | Alpha-2 adrenergic receptor subtype C10 | Up | Yes | |
ADRA2C | Alpha-2 adrenergic receptor subtype C4 | Up | Yes | |
ALK | ALK tyrosine kinase receptor, anaplastic lymphoma kinase Ki-1 | Up | Yes | |
ANK2 | Ankyrin 2 | Up | Yes | |
ASS | Argininosuccinate synthase | Up | ? | |
ASTN2 | Astrotactin 2 | Up | Yes | |
BIN1 | Bridging integrator 1 | Down | Yes | |
BMP5 | Bone morphogenic protein 5 | Up | Yes | |
C10ORF6 | Family with sequence similarity 178, member A | Up | Yes | |
CCND1 | Cyclin D1 | Down | ? | |
CD9 | CD9 molecule/Tetraspanin-29 | Up | Yes | |
CDH3 | Cadherin 3, type 1, P-cadherin (placental) | Up | Yes | |
CHD7 | Chromodomain helicase DNA-binding protein 7 | Up | Yes | |
CKM | Creatine kinase M chain, muscle | Up | Yes | |
CNR1 | Cannabinoid receptor 1 | Up | Yes | |
COL18A1 | Collagen type 18 α 1 | Up | ? | |
CXCR4 | C-X-C chemokine receptor type 4 | Up | Yes | |
CXCR7 | C-X-C chemokine receptor type 7 | Down | Yes | |
DCX | Neuronal migration protein doublecortin | Up | ? | |
DES | Desmin | Down | Yes | |
DKFZP762M127 | Unknown | Up | Yes | |
DUSP4 | Dual specificity phosphatase 4 | Down | ? | |
DZIP3 | DAZ interacting protein 3, zinc finger | Up | Yes | |
ELA1 | Elastase-1 | Up | Yes | |
ENC1 | Ectodermal-neural cortex 1 (with BTB-like domain) | Up | Yes | |
ENO3 | Enolase 3 (beta, muscle) | Up | ? | |
EPHA4 | Ephrin type-A receptor 4 | Up/down | Yes | |
FGFR2 | Fibroblast growth factor receptor 2 | Up | Yes | |
FGFR4 | Fibroblast growth factor receptor 4 | Up | Yes | |
FLNB | Filamin B, beta | Down | Yes | |
FNBP1 | Formin-binding protein 1 | Down | ? | |
FOXF1 | Forkhead box protein F1 | Up | Yes | |
FOXO1 | Forkhead box O1 | Up | Yes | |
GADD45A | Growth arrest and DNA-damage-inducible protein GADD45 alpha | Up | Yes | |
GRAF | GTPase regulator associated with FAK | Up | Yes | |
GTF3C1 | General transcription factor 3C | Up | Yes | |
H19 | Imprinted maternally expressed gene, untranslated mRNA | Up | Yes | |
HDAC5 | Histone deacetylase 5 | Up | Yes | |
HUMMLC2B | Myosin regulatory light chain 2, skeletal muscle isoform | Down | Yes | |
IGF2 | Insulin-like growth factor II | Up | Yes | |
IGFBP3 | IGF-binding protein 3 | Down | Yes | |
IGFBP5 | IGF-binding protein 5 | Up | [5] | Yes |
IL4R | Interleukin 4 receptor | Up | Yes | |
JAKMIP2 | Janus kinase and microtubule-interacting protein 2 | Up | Yes | |
KCNN3 | Small conductance calcium-activated potassium channel protein 3 | Up | Yes | |
KCNS3 | Potassium voltage-gated channel subfamily S member 3 | Up | ? | |
LRRFIP2 | Leucine-rich repeat (in FLII) interacting protein 2 | Up | Yes | |
MARCH3 | Membrane-associated RING finger protein 3 | Up | Yes | |
MCAM | Melanoma cell adhesion molecule | Up | Yes | |
MEG3 | Maternally expressed 3 | Up | ? | |
MN1 | Meningioma (disrupted in balanced translocation) 1 | Up | Yes | |
MET | Hepatocyte growth factor receptor | Up | Yes | |
MTUS2 | Microtubule associated tumor suppressor candidate 2 | Up | Yes | |
MYBPH | Myosin-binding protein H | Up/down | Yes | |
MYCN | N-MYC proto-oncogene protein | Up | Yes | |
MYH8 | Myosin, heavy chain 8, skeletal muscle, perinatal | Up/down | Yes | |
MYL1 | Myosin, light chain 1, alkali; skeletal, fast | Up/down | Yes | |
MYL4 | Myosin, light chain 4, alkali; atrial, embryonic | Up/down | Yes | |
MYOD | Myoblast determination protein 1 | Up | Yes | |
MYOG | Myogenin (myogenic factor 4) | Up | Yes | |
NEBL | Nebulette | Up/down | Yes | |
NELL1 | NEL-like protein 1 | Up | Yes | |
NHLH1 | Nescient helix loop helix 1 | Up | Yes | |
NPTX2 | Neuronal pentraxin II | Down | Yes | |
NRCAM | Neuronal cell adhesion molecule | Up | Yes | |
OLIG2 | Oligodendrocyte transcription factor 2 | Up | ? | |
PALMD | Palmdelphin | Down | Yes | |
PBK | PDZ-binding kinase | Up | Yes | |
PCDH7 | Protocadherin 7 | Up | Yes | |
PDZRN3 | PDZ domain containing ring finger 3 | Up | Yes | |
PGBD5 | PiggyBac transposable element-derived protein 5 | Up | Yes | |
PHF17 | PHD finger protein 17 | Up | Yes | |
PIPOX | Pipecolic acid oxidase | Up | Yes | |
PKP1 | Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) | Up | Yes | |
PLAG1 | Pleiomorphic adenoma gene 1 protein | Down | Yes | |
PLK2 | Polo-like kinase 2 | Down | Yes | |
PODXL | Podocalyxin-like protein 1 | Up | Yes | |
POU4F1 | Brain-specific homeobox/POU domain protein 3A | Up | Yes | |
PPARGC1A | Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Up | Yes | |
PRKAR2B | Protein kinase, cAMP-dependent, regulatory, type II, beta | Up | Yes | |
PRKCA | Protein kinase C, alpha | Up | Yes | |
PSEN2 | Presenilin 2 (Alzheimer’s disease 4) | Up | ? | |
PTHLT | Parathyroid hormone-like hormone | Up | Yes | |
QDPR | Quinoid dihydropteridine reductase | Up | Yes | |
RASSF4 | Ras association (RalGDS/AF-6) domain family 4 | Up | Yes | |
RRP22 | Ras-like protein family member 10A, on chm 22 | Up | ? | |
RYR1 | Skeletal muscle-type ryanodine receptor | Up | Yes | |
RYR3 | Brain-type ryanodine receptor | Up | Yes | |
SLC24A3 | Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | Up | Yes | |
SIX1 | SIX homeobox 1 | Up | Yes | |
SOX14 | SRY (sex determining region Y)-box 14 | Up | Yes | |
STX11 | Syntaxin 11 | Up | Yes | |
SULF1 | Sulfatase 1 | Up | Yes | |
SVIL | Supervillin | Down | Yes | |
TCF712 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | Up | Yes | |
TGFB1 | Transforming growth factor, beta 1 | Up | Yes | |
TFAP2B | Transcription factor AP-2 beta | Up | Yes | |
TIAF1 | TGF-beta-1-induced antiapoptotic factor 1 | Up | ? | |
TM4SF10 | Transmembrane 4 superfamily member 10 | Up | Yes | |
TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 | Up | Yes | |
TNNC2 | Troponin C type 2 (fast) | Up/down | Yes | |
TNNI2 | Troponin I type 2 (skeletal, fast) | Up/down | Yes | |
TNNT2 | Troponin T type 2 (cardiac) | Up | Yes | |
TNNT3 | Troponin T type 3 (skeletal, fast) | Down | Yes | |
TRAM2 | Translocation-associated membrane protein 2 | Up | Yes | |
TSC22D2 | TSC22 domain family, member 2 | Up | Yes | |
UBE2G2 | Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) | Up | Yes | |
WSCD1 | WSC domain-containing protein 1 | Up | ? | |
WVA5A | Von Willebrand factor A domain containing 5A | Up | Yes |