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Figure 1 | Skeletal Muscle

Figure 1

From: Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting

Figure 1

A schematic of the HSA-MCM transgene. The promoter and first exon (−2,000 to +239 relative to the transcription start site) of the human α-skeletal actin (HSA) gene drives expression of the MerCreMer (MCM) gene which harbors a m utated e strogen r eceptor (Mer) ligand-binding domain on each terminus of the Cre recombinase gene. The β-globin intron ΙΙ (BGI) and poly(A) tail were incorporated into the transgene to ensure proper splicing and transcript stability, respectively. The positions of the PCR primers used for genotyping are indicated by half-arrows.

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