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Table 2 Some of the important autoantibodies reported in inflammatory myopathies

From: Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness

Autoantibodies Disease Association References
Anti-tRNA synthetases1 (Anti-Jo; against histidyl tRNA synthetase) More common in PM than DM Interstitial lung disease [6365]
Anti-chromodomain helicase DNA binding proteins (anti-Mi2) DM Cutaneous lesions [3, 66, 67]
Anti-MDA5/Anti-CADM-140 DM Mucocutaneous lesions; severe lung disease minimal muscle involvement [6870]
Anti-TIF1γ2 DM Malignancy [7173]
Anti-nuclear matrix protein (NXP)-2/anti-MJ Mostly juvenile DM Joint contractures; calcinosis [74]
Anti-SAE3 DM Skin and muscle manifestations [75]
Anti-signal recognition particle NM, PM Degenerating and regenerating muscle fibers and possible cardiac involvement [7679]
Anti-HMG-CoA reductase4 Statin associated myopathy Treatment with cholesterol lowering drugs [80, 81]
  1. PM Polymyositis, DM Dermatomyositis, NM Necrotizing myopathy.
  2. 1Additional antisynthetase antibodies found in myositis are targeted against threonyl-tRNA synthetase (PL-7); alanyl-tRNA synthetase (PL-12); isoleucyl-tRNA synthetase (OJ); glycyl-tRNA synthetase (EJ); asparaginyl-tRNA synthetase (KS).
  3. 2TIF1γ: Transcription intermediary factor 1γ.
  4. 3SAE: Small ubiquitin like modifier activating enzyme.
  5. 4HMG-CoA reductase: 3-hydroxy-3-methylglutaryl-coenzymeA reductase.