Skip to main content
Figure 5 | Skeletal Muscle

Figure 5

From: Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers

Figure 5

Schematic model of GLUT4 and MT distribution in wt, mdx , cKO, and dKO myofibers. Plasma membrane resident GLUT4 and juxtamembrane-positioned MTs are depicted as being reduced in (P1f- overexpressing) mdx myofibers compared to the other genotypes; whereas in cKO and dKO myofibers subsarcolemmal MT network densities are increased. The model makes differences in MT network density and membrane anchorage accountable for how efficiently GLUT4-containing vesicles are transported towards the sarcolemma, with a low point in the case of mdx muscle.

Back to article page

Skeletal Muscle

ISSN: 2044-5040

Contact us