Figure 7
From: Murine Fig4 is dispensable for muscle development but required for muscle function
Transgenic (Tg) neuronal rescue of FIG4 expression largely restores plt myofiber size. (A) Hematoxylin and eosin–stained sections of gastrocnemius muscle from wild-type (WT) and Fig4−/−/NSE-FIG4 (that is, plt with transgenic expression of Fig4 driven by the neuron-specific enolase (NSE) promoter). The plt muscle is essentially indistinguishable from WT, with the exception of mild reduction in fiber size. (B) Quantification of myofiber size from quadriceps muscles of 8-month-old Fig4−/−/NSE-FIG4 and WT animals. There was a small but significant reduction in total fiber area in transgenically rescued plt muscle: 2,799 μm2 ± 165 for WT vs 2,322 μm2 ± 121 for plt (n = 60, P = 0.02). (C) Transmission electron photomicrographs from tibialis anterior muscle. Normal triads and mitochondria were present in both WT and plt/Tg-NSE-Fig4 animals.