Isolated fibers from YS mice exhibit increased sensitivity to simvastatin compared to WT mice. Dose–response curves from isolated WT and YS FDB fibers incubated for 3 minutes in respective doses of simvastatin. Data points reflect peak cytosolic Ca2+ change from baseline, indicating that fibers from YS mice respond to simvastatin at lower doses than WT fibers. Fibers were used only at a single simvastatin concentration. Each data point represents the mean cytosolic Ca2+ response from a minimum of three fibers taken from three separate mice. Ca2+, calcium; FDB, flexor digitorum brevis; WT, wild type; YS, Y524S.