Figure 4
From: Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin
Pre-treatment with AICAR reduces the cytosolic Ca2+response to simvastatin. Pre-incubation with AICAR prevents Ca2+ release in (A) YS fibers exposed to 500 μM simvastatin (P <0.01) and in (B) WT fibers exposed to 1 mM simvastatin (P <0.001). (C) YS and (D) WT show change in Ca2+ concentration for AICAR-treated (dashed) and untreated (solid) fibers after exposure to either 500 μM (YS) or 1 mM (WT) simvastatin at 2 minutes . AICAR, 5-aminoimidazole-4-carboxamide ribonucleoside; Ca2+, calcium; WT, wild type; YS, Y524S.