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Figure 3 | Skeletal Muscle

Figure 3

From: Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

Figure 3

Rb1 inactivation decreases latency of rhabdomyosarcoma in with the context of dual Pax3:Foxo1a activation and p53 inactivation. (A) Kaplan–Meier survival curve of RMS-free survival in mice with Rb1 inactivation, p53 inactivation or Pax3:Foxo1a activation in the Myf6cre lineage. Any of these genetic events alone is generally not sufficient for the development of RMS. (B) Survival analysis of Pax3:Foxo1a,p53; Pax3:Foxo1a,Rb1, and p53,Rb1 mice (all using Myf6cre). The results suggest that Rb1 loss, unlike p53 inactivation, has no cooperative effects with Pax3:Foxo1a activation for the development of RMS. (C) Addition of Rb1 inactivation to Pax3:Foxo1a activation and p53 deletion significantly accelerated rhabdomyosarcomagenesis compared with Pax3:Foxo1a,p53 mice (log-rank test, P <0.01; all experiments using Myf6cre). The mean latency for sarcoma development was 67 days in Pax3:Foxo1a,p53,Rb1 mice and 107 days in Pax3:Foxo1a,p53 mice. (D) Tumor stage (top) and anatomical site (bottom) of mice corresponding to (A) to (C).

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