Figure 2

NBD treatment improves extension force in GRMD dogs. Wild type and GRMD dogs were administered NBD IV at 10 mg/kg dose, 3× weekly for 4 months. Tibiotarsal joint (TTJ) tetanic extension (A) and flexion (B) force were measured in NBD-treated wild type and GRMD dogs and compared to untreated wild type GRMD control data from a separate natural history study. Extension force was significantly increased (P <0.05 [*]) in NBD-treated GRMD dogs compared to untreated dogs. Flexion force was lower in GRMD dogs treated with NBD but the difference was not significant. White bars represent wild type dogs, while black bars represent GRMD dogs, either untreated or treated with NBD.