Table 1 Phenotypic measures in NBD-treated and untreated GRMD and normal dogs

Body Mass (kg)

8.46 ± 0.63^2*

17.80 ± 0.44^1***,2***

4.99 ± 1.83

21.10 ± 3.15^1*

7.36 ± 1.29

13.40 ± 2.20^1***

3.60 ± 0.27

12.70 ± 2.81^1**

Absolute Tetanic Flexion Force (N)

9.51 ± 1.07^2***

23.19 ± 2.20^1***,2***

4.52 ± 1.82

25.75 ± 2.18^1**

3.85 ± 1.13

7.85 ± 1.98^1***

2.05 ± 0.58

6.79 ± 1.13^1***

Body-mass Corrected Tetanic Flexion Force (N/kg)

1.12 ± 0.10^2***

1.30 ± 0.13^1*,2***

0.90 ± 0.04^2**

1.24 ± 0.19

0.53 ± 0.14

0.62 ± 0.18

0.57 ± 0.15

0.55 ± 0.13

Absolute Tetanic Flexion Torque (Nm)

1.08 ± 0.14^2***

3.22 ± 0.35^1***,2***

0.42 ± 0.24

3.65 ± 0.43^1**

0.43 ± 0.14

1.03 ± 0.23^1***

0.17 ± 0.06

0.89 ± 0.18^1***

Body-mass Corrected Tetanic Flexion Torque (Nm/kg)

0.13 ± 0.01^2***

0.18 ± 0.02^1***,2***

0.08 ± 0.02

0.17 ± 0.02

0.06 ± 0.02

0.08 ± 0.02

0.05 ± 0.01

0.07 ± 0.02^1*

Absolute Tetanic Extension Force (N)

22.56 ± 2.76^2***

46.43 ± 8.44^1***,2***

13.46 ± 3.26

42.17 ± 7.46^1*

12.73 ± 2.12

18.47 ± 10.11

7.50 ± 2.09

34.30 ± 9.65^1**,2*

Body-mass Corrected Tetanic Extension Force (N/kg)

2.68 ± 0.38^2**

2.61 ± 0.49^2**

2.88 ± 1.10

2.00 ± 0.22

1.80 ± 0.52

1.56 ± 0.92

2.11 ± 0.70

2.70 ± 0.65^2*

Absolute Tetanic Extension Torque (Nm)

2.55 ± 0.37^2***

6.44 ± 1.24^1***,2***

1.20 ± 0.41

6.02 ± 1.38^1*

1.42 ± 0.23

2.46 ± 1.28

0.62 ± 0.16

4.55 ± 1.49^1**,2*

Body-mass Corrected Tetanic Extension Torque (Nm/kg)

0.30 ± 0.04^2***

0.36 ± 0.07^2***

0.25 ± 0.08

0.28 ± 0.04

0.20 ± 0.05

0.18 ± 0.10

0.21 ± 0.07

0.36 ± 0.08^1*,2**

ECD (%; 1-10)

13.68 ± 3.97

8.29 ± 2.88^1*,2**

13.36 ± 2.65

14.47 ± 7.31

13.97 ± 10.52

28.96 ± 18.07

16.12 ± 5.88

32.04 ± 13.46

ECD (%; 1-30)

26.80 ± 5.92^2*

17.86 ± 5.20^1*,2***

33.44 ± 10.3

23.25 ± 17.4

36.51 ± 11.49

54.30 ± 14.73^1*

38.67 ± 10.34

54.48 ± 13.64

TTJ Angle (^o)

167.9 ± 3.94^2***

160.9 ± 3.40^1**,2*

161.7 ± 7.64

158.3 ± 2.08

159.40 ± 3.72

151.30 ± 10.19

157.00 ± 9.80

160.17 ± 8.84

Hip (Resting)

99.50 ± 5.10

104.4 ± 5.76

99.33 ± 1.15

103.0 ± 11.4

103.4 ± 8.96^{^}

109.6 ± 8.02

103.7 ± 2.94

100.2 ± 6.01^2*

Maximum Hip Flexion (^o)

55.50 ± 8.86

59.00 ± 12.60

48.67 ± 7.77

53.33 ± 10.12

54.40 ± 7.50^{^}

68.60 ± 16.15

44.67 ± 5.47

46.33 ± 3.50^2**

Pelvic Angle (^o)

43.75 ± 5.12

36.14 ± 5.98^2**

38.33 ± 1.53

40.33 ± 5.03

40.00^#

48.30 ± 5.54

41.00 ± 6.81

36.83 ± 5.12^2**

CS Circumference (mm/kg)

NA

2.09 ± 0.40^2***

NA

2.30 ± 0.49

NA

4.03 ± 1.04

NA

3.67 ± 0.65