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Table 2 MRI T2 and texture analysis features in NBD-treated and untreated GRMD and wild type dogs

From: NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy

Muscle

Normal (Untreated) (n = 8)

Normal (NBD-treated) (n = 3)

GRMD (Untreated) (n = 10)

GRMD (NBD-treated) (n = 6)

T2

SLI

HI

T2

SLI

HI

T2

SLI

HI

T2

SLI

HI

Cranial Sartorius

49.40 ± 9.01

0.79 ± 0.09

66.80 ± 18.58

47.72 ± 6.86

0.74 ± 0.04

59.82 ± 29.72

49.87 ± 6.44

0.79 ± 0.05

74.01 ± 27.15

49.40 ± 9.01

0.79 ± 0.05

59.82 ± 14.91

Caudal Sartorius

53.87 ± 9.88

0.72 ± 0.12

27.96 ± 15.47

54.02 ± 4.79

0.81 ± 0.04

35.21 ± 9.28

59.71 ± 7.02

0.83 ± 0.07

56.90 ± 30.08

53.87 ± 9.88

0.83 ± 0.05

35.21 ± 14.92

Vastus Lateralis

40.67 ± 5.84

0.62 ± 0.07

66.18 ± 28.71

36.60 ± 1.37

0.63 ± 0.12

52.92 ± 23.51

49.84 ± 5.35

0.75 ± 0.07

69.42 ± 18.85

40.67 ± 5.84^

0.68 ± 0.04^

52.92 ± 27.20

Vastus Intermedius

41.91 ± 5.91

0.66 ± 0.19

42.44 ± 21.75

36.03 ± 0.73^

0.58 ± 0.06

59.10 ± 9.05

52.62 ± 6.33

0.75 ± 0.06

69.83 ± 39.19

41.91 ± 5.91^

0.68 ± 0.09

59.10 ± 27.19

Vastus Medialis

42.74 ± 5.65

0.72 ± 0.11

63.20 ± 23.57

35.80 ± 0.94^

0.64 ± 0.06

52.55 ± 9.41

53.60 ± 7.16

0.82 ± 0.06

41.13 ± 14.73

42.74 ± 5.65

0.77 ± 0.09

52.55 ± 22.29

Rectus Femoris

37.23 ± 4.72

0.70 ± 0.06

55.30 ± 29.46

33.30 ± 2.41

0.64 ± 0.03

55.42 ± 3.46

49.44 ± 5.71

0.78 ± 0.06

57.02 ± 23.66

37.23 ± 4.72

0.68 ± 0.07^

55.42 ± 21.95

Biceps Femoris

40.20 ± 4.91

0.67 ± 0.06

91.36 ± 35.35^

34.94 ± 0.40

0.62 ± 0.07

87.50 ± 11.65

50.13 ± 4.78

0.76 ± 0.06

137.3 ± 40.91

40.20 ± 4.91^

0.68 ± 0.06^

87.50 ± 48.42

Semimembranosus

39.42 ± 4.86

0.63 ± 0.08

49.75 ± 20.32

35.24 ± 1.17

0.63 ± 0.10

78.15 ± 20.38

52.28 ± 4.55

0.71 ± 0.07

121.4 ± 59.04

39.42 ± 4.86

0.68 ± 0.06

78.15 ± 33.31

Semitendinosus

40.41 ± 4.97

0.61 ± 0.19

44.65 ± 21.35

36.59 ± 2.18

0.61 ± 0.13

81.43 ± 38.69

56.09 ± 6.02

0.77 ± 0.07

128.1 ± 42.03

40.41 ± 4.97^

0.67 ± 0.08^

81.43 ± 35.00

Adductor

39.52 ± 4.76

0.67 ± 0.11

87.90 ± 42.89

34.69 ± 0.91^

0.64 ± 0.00

116.18 ± 7.79

50.49 ± 5.19

0.72 ± 0.05

84.12 ± 33.68

39.52 ± 4.76

0.72 ± 0.02

116.2 ± 22.37

Gracilis

45.91 ± 3.50

0.63 ± 0.13

59.83 ± 38.30

38.27 ± 0.93**

0.62 ± 0.06

58.90 ± 24.51

58.56 ± 5.19

0.78 ± 0.05

104.2 ± 34.65

45.91 ± 3.50

0.70 ± 0.06^

58.90 ± 30.66

All

40.81 ± 0.47

0.66 ± 0.08

71.06 ± 27.89

35.90 ± 0.47^

0.63 ± 0.04

47.12 ± 10.24

52.28 ± 4.52

0.75 ± 0.04

103.47 ± 22.40

47.34 ± 3.10^

0.70 ± 0.04^

86.01 ± 18.28

  1. MRI values are shown for individual thigh muscles. A composite value for all muscles combined is also shown. Significantly different or trending towards different from untreated control, same genotype; **indicates statistical difference from untreated control, same genotype p < 0.01; ^indicates trending towards different from untreated control, same genotype p < 0.10.