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Figure 6 | Skeletal Muscle

Figure 6

From: Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

Figure 6

PP2Cα knockdown prevented caspase-3 activation and Rpt6 cleavage. All data were generated from experiments utilizing PP2Cα siRNA ‘A’. (A) 17 KDa activated caspase-3 was increased by AngII, and this increase was prevented by PP2Cα knockdown. (B) The proteasome 19S cap ATP-ase Rpt6 (a target of caspase-3) cleavage was increased with AngII, and this cleavage was blunted by PP2Cα knockdown. (C) Ubiquitin-conjugated protein was increased with AngII, but not significantly reduced by PP2Cα siRNA. n =6-32 per group, Mean ± SEM, *P <0.05, ****P <0.0001 (Saline scrambled vs. AngII scrambled), +P <0.05, +++P <0.001 (AngII scrambled vs. AngII PP2Cα siRNA).

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Skeletal Muscle

ISSN: 2044-5040

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