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Table 1 Cumulative muscle damage in exercised mdx mice treated or not with andrographolide

From: Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

 

Necrosis

Regeneration

Cumulative damage

mdx + vehicle

7.63 ± 0.85

42.14 ± 4.03

49.77 ± 4.61

mdx + andrographolide

4.14 ± 0.51b

30.23 ± 2.86a

34.37 ± 2.97a

  1. Cumulative skeletal muscle damage in mdx mice consists of active myofiber necrosis plus the areas of subsequent regeneration (new myofibers). Values shown are average percentage (%) of whole cross-sectional area +/− SEM (values were analyzed by a t-test, n = 5, aP < 0.05) [38]. bP < 0.01.