Distinct roles of long noncoding RNAs (lncRNAs) in muscle differentiation. (A) Enhancer RNAs (eRNAs) CE and DRRRNAs can induce expression of myogenic regulators MyoD and MyoG acting in cis or in trans, respectively. (B) LncRNA SRA acts as a scaffold molecule for MyoD, p68 and p72 at the promoter region of myogenic genes to activate their expression. (C) LncRNAs Malat1, H19 and Gtl-Meg3 interact with PRC1/2 complex to modulate their target genes. (D) As a molecular sponge H19 inhibits let-7 mediated mRNA degradation of myogenic negative regulators Hmga2 and Igfbp2. (E) Short interspersed element (SINE) containing lncRNAs can bind to UTR region of Cdc6 and Traf6 mRNAs and promote their decay at different stages of muscle differentiation.