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Figure 5 | Skeletal Muscle

Figure 5

From: The miR-206/133b cluster is dispensable for development, survival and regeneration of skeletal muscle

Figure 5

No transcriptional changes in the soleus muscle of miR-206/133b knock-out (KO) mice. The scatter blot of the median of the log2 signals of wildtype (WT) (n = 9) versus KO (n = 8) indicates only few genes with expression changes more than twofold (green lines). The probe set 1446563_at detects RNA originating from the genome between miR-206 and miR-133b most likely the pri-miRNA of these miRNAs. The weak signal for this probe set in WT samples is reduced to the detection limit in the KO samples. Only a few of the detected changes in gene expression are significant after statistical analysis using Student’s t-test. None of these changes could be verified by quantitative reverse transcription PCR (qRT-PCR) or analysis of protein expression. After false discovery rate correction by the Benjamini-Hochberg algorithm, only one gene directly downstream of the manipulated genomic locus significantly changed expression.

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