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Figure 9 | Skeletal Muscle

Figure 9

From: The miR-206/133b cluster is dispensable for development, survival and regeneration of skeletal muscle

Figure 9

miR-206/133b mutation does not modulate muscle loss or regeneration in Mdx mice. No histological changes are observed in diaphragm or M. quadriceps after loss of miR-206/133b. Mutation of the mouse dystrophin gene (MDX) leads to increased muscle mass, calcifications (von Kossa staining) and increased fibrosis (red signal in Sirius red staining). Additional loss of miR-206/133b does not lead to changes of the mdx phenotype. Sections obtained from 12 weeks old animals are shown, similar results are obtained using tissue from 6-week- and 9-month-old mice. The scale bar corresponds to 200 μm in the upper three rows and to 50 μm in the lower two rows.

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