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Figure 1 | Skeletal Muscle

Figure 1

From: X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene

Figure 1

Clinical presentations and family history of affected dogs. Photographs of the healthy dam II-2 (A), sire II-3 (B), and two affected male littermates III-12 (C) and III-13 (D) at 12 weeks of age. (E) Pedigree of the two affected Rottweiler litters with male puppies that presented with progressive muscle weakness. The 15 members whose DNA was available for analysis are indicated by an asterisk. Squares = males, circles = females, SB = still born. Filled symbols indicate clinically affected. The dot in the center of II-2 indicates her genetically confirmed status as a carrier for the MTM1 mutation illustrated below.

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Skeletal Muscle

ISSN: 2044-5040

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