Figure 6

Ablation of CSQ1-induced RyR1 regulation is due to significant changes in channel P _o , T _o , and T _c . Average relative data (relative to activity before the addition of CSQ1 constructs; N = 8) showing P _o , T _o , T _c , and F _o . (A) Relative P _o (log rel P _o ) is the average of differences between the log10 of P _o in the presence of CSQ1 constructs (logP _oCSQ) and log10 of the control P _o (logP _oCon; in the absence of CSQ1) for each channel. (B) The relative mean open time (log rel T _o ) is logT _oCSQ − logT _oCon . (C) The relative mean closed time (log rel T _c ) is log T _cCSQ − log T _cCon . (D) The relative mean open frequency (log rel F _o ) is logF _oCSQ − logF _oCon . Average data significantly different (P ≤ 0.05) from channel activity recorded in the absence of WT CSQ1 is indicated by asterisk (*) and in the presence of WT CSQ1 indicated by crosshatch (#). Data were recorded at +40 and −40 mV.