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Figure 5 | Skeletal Muscle

Figure 5

From: Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

Figure 5

Loss of Mef2c function in skeletal muscle results in exercise-induced inclusions in muscle. (A, B, D, E) Ultrastructural analysis of the soleus muscle from exercised (Run) and unexercised (No Run) mice was determined by electron microscopy (EM) at 8,000× magnification. (A, D) Unexercised control (A) and Mef2c SkMKO (D) mice each displayed well-organized sarcomeres prior to exercise. (B, E) After exercise, both control and Mef2c SkMKO mice had an increase in mitochondria (arrows). Exercised Mef2c SkMKO mice also had increased accumulation of large vacuolar inclusion bodies (arrowheads) in between the sarcomeres (E). (C, F) Sections from exercised control and Mef2c SkMKO mice stained with toluidine blue and imaged at 20× magnification revealed inclusions (arrows) and centrally located nuclei (arrowheads) within the muscle fibers of Mef2c SkMKO mice following exercise (F).

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