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Figure 5 | Skeletal Muscle

Figure 5

From: Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice

Figure 5

Age-dependant decrease in cross-sectional area (CSA) of EDL fibers. Frequency distributions (A-C) and average CSA (D) of individual EDL fibers at three different ages. Average fiber CSA is significantly reduced in CASQ1-null mice compared to age-matched WT mice across all age groups tested. Note that CSA of fibers decreases with age in both genotypes (D), but the major reduction in fibers from CASQ1-null mice occurs from 4 to 6 months to 14 months of age, whereas this reduction occurs later in WT mice (that is, between 14 and 24 months). Data given in μm2 are expressed as means ± SEM (**P < 0.01). EDL, extensor digitorum brevis; CASQ1, skeletal isoform of calsequestrin; WT, wild type.

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